Osborne 204A

Metals are required for life, and microbes have evolved small molecules to compete for, acquire, and utilize metals. Systematic methods for the discovery of metal-small molecule complexes from biological samples remain limited, precluding their discovering and functional characterization. In this seminar, I will describe a native electrospray ionization mass spectrometry-based method, in which post-column metal-infusion and pH adjustment is combined with ion identity molecular networking. As this native metal metabolomics approach can be easily implemented on any liquid chromatography-based mass spectrometer, this method has the potential to become a key strategy for elucidating and understanding the role of metal-binding molecules in biology. In my laboratory, we have applied this technology elucidate metal-binding molecules from host-associated and environmental microbiomes.    

Hosted by: Department of Physics & Energy Science, UCCS Physics Club

Additional Information can be found at: https://mlc.uccs.edu/event/11076601

ThoughtfulLearning, Academic Lecture, Seminar, Natural Sciences